Resomelagon proposed international nonproprietary name (INN) for AP1189

SynAct Pharma AB (publ) (“SynAct”) today announced that a name, resomelagon, for the chemical structure of AP1189 is included in the list of Proposed International Nonproprietary Names (INN), INN Proposed List 127, published by World Health Organization (WHO).

The systematic chemical name for the structure of AP1189 is (2E)-2-{(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]prop-2-en-1-ylidene}hydrazine-1-carboximidamide, and will be referred to as resomelagon, if the name will be included on WHO’s list of recommended INNs. The inclusion on the list of recommended INNs is subject to WHO’s procedure, and is expected to be concluded by Q1 2023

The inclusion of a name in the lists of Proposed International Nonproprietary Names does not imply any recommendation of the use of the substance in medicine or pharmacy.

The name resomelagon has been proposed to reflect that AP1189 is promoting resolution of inflammation by acting as a melanocortin receptor agonist and is following WHO’s principles for assigning INNs to novel chemical structures.

The information was submitted, through the agency of the contact person below, for publication at 07:00 a.m. CEST on August 16, 2022.